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These regions behave like city-states, where there is significant intra-regional trade, communications, and distribution of goods. They also share similar culture, geography, and climate that facilitate (or cause) their similarities.
They usually have one or few “capital” cities that are the hubs. Chicago, LA, Seattle, Atlanta, Phoenix, etc.
Edit: I’d also like to add that many of these “connections” between cities and the putative capital or capital**s** are underneath everyday life. Where does your local McD’s or Walmart get their stuff distributed? How much money travels between the cities versus outside? How many people move within these regions versus outside? Where do major trucking routes occur?
Sure these are all hypotheses, and nothing that is presented is definite. Many anecdotal counterexamples exist, but does this mean there is a total lack of evidence, or is there just one possible interpretation/analysis among many? This is r/mapporn, and maps exist to help us see things that we can’t perceive already – let it be boundaries, scale, or things that can’t be measured by miles.
Thanks for u/systemstheoriest for the link [here](http://www.america2050.org/content/megaregions.html#more) highlighting these are *trajectories* and not how things actually are right now – so to better inform planning and finance in the future.